BODIPY-Au(I): A Photosensitizer for Singlet Oxygen Generation and Photodynamic Therapy.

Muhammed ÜçüncüErman KarakuşEylem Kurulgan DemirciMelike SayarSuay DartarMustafa Emrullahoglu

Published in: Organic letters (2017)

Upon complexation with Au(I), a photoinactive BODIPY derivative was transformed into a highly photoactive triplet sensitizer. Along with high efficiency in singlet oxygen generation (ΦΔ = 0.84), the new BODIPY-Au(I) skeleton showed excellent photocytotoxic activity against cancer cell lines (EC50 = 2.5 nM).

Keyphrases

photodynamic therapy
high efficiency
fluorescent probe
sensitive detection
living cells
reduced graphene oxide
fluorescence imaging
energy transfer
papillary thyroid
quantum dots
visible light
gold nanoparticles
squamous cell carcinoma
childhood cancer