CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer.

Elio AdibTalal El ZarifAmin H NassarElie W AklSarah Abou AlaiwiTarek H MouhieddineEdward D Esplin Kathryn E HatchellSarah M NielsenHuma Q RanaToni K Choueiri David J Kwiatkowski Guru P Sonpavde

Published in: British journal of cancer (2021)

We report for the first time the prevalence of P/LP CDH1 variants across several cancers and show significant enrichment in CDH1 P/LP variants for patients with CSRCC, DGC, and LBC across various ethnicities. Future prospective studies are warranted to validate these findings.

Keyphrases

copy number
risk factors
current status
gene expression
case control