Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies.

Leonard J ApplemanJan H BeumerYixing JiangYan LinFei DingShannon PuhallaLeigh SwartzTaofeek K OwonikokoR Donald HarveyRonald StollerDaniel P PetroHussein A TawbiAthanassios ArgirisSandra StrychorMarie PouquetBrian KieselAlice P ChenDavid GandaraChandra P BelaniEdward ChuSuresh S Ramalingam

Published in: Cancer chemotherapy and pharmacology (2019)

Veliparib, paclitaxel, and carboplatin were well tolerated and demonstrated promising antitumor activity.

Keyphrases

phase ii study
open label
phase iii
placebo controlled
double blind
squamous cell carcinoma
locally advanced
structural basis