Fabrication of polydopamine-modified cellulose hydrogel for controlled release of α-mangostin.
Hoang Lich PhanNgoc Cam Trang TranThi Hoang Yen LeQuoc-Viet LeTran-Thai-Duong LeUt Dong ThachPublished in: Biopolymers (2024)
Hydrogels are notable for their outstanding absorbent qualities, satisfactory compatibility with biological systems, ability to degrade, and inherent safety, all of which contribute to their high demand in the field of biomedicine. This study focuses on the fabrication of hydrogels using environmentally friendly cellulosic material. Cellulose hydrogel beads were prepared by physical cross-linking in a NaOH/urea medium. Furthermore, nano polydopamine was integrated into the hydrogel matrix as functional polymers and α-mangostin was employed as an active pharmaceutical ingredient. The physicochemical properties were comprehensively analyzed using Fourier-transform infrared spectrometer, 13 C cross-polarization/magic angle spinning nuclear magnetic resonance, thermogravimetric analysis, and scanning electron microscope. The drug delivery properties, including water content, swelling ratio, and drug release profiles, were evaluated. In vitro cytotoxicity against MC3T3-E1 cells was assessed using sulforhodamine B staining. All test hydrogels exhibited inhibitory activity against the growth of MC3T3-E1 cells. These results indicated the potential use of these hydrogels as a drug delivery carrier for α-mangostin in the treatment of ankylosing spondylitis.
Keyphrases
- drug delivery
- drug release
- ankylosing spondylitis
- cancer therapy
- induced apoptosis
- tissue engineering
- magnetic resonance
- cell cycle arrest
- hyaluronic acid
- high resolution
- rheumatoid arthritis
- cell death
- mental health
- computed tomography
- disease activity
- low cost
- climate change
- magnetic resonance imaging
- pi k akt
- human health