EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis.

Kun WangYiyang WangYuanjian WangShujie LiuChunyan WangShuo ZhangTianli ZhangXingsheng Yang

Published in: Stem cell research & therapy (2021)

Our results imply that EIF5A2 positively regulates stemness in ovarian cancer cells via E2F1/KLF4 pathway and may serve as a potential target in CSCs-targeted therapy for ovarian cancer.

Keyphrases

stem cells
cancer stem cells
epithelial mesenchymal transition
induced apoptosis
transcription factor
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
cell death
oxidative stress
drug delivery
risk assessment
climate change