Polymyxin B vs. colistin: the comparison of neurotoxic and nephrotoxic effects of the two polymyxins.
Pınar Aysert-YıldızÖzge Özgen-TopAhmet Furkan ŞentürkSait KanikHasan Selçuk ÖzgerMurat DizbayPublished in: BMC infectious diseases (2024)
Neurotoxicity is a relatively common adverse event that leads to drug withdrawal during polymyxins, particularly polymyxin B. Nephrotoxicity is very common during polymyxin therapy and the two polymyxins display similar nephrotoxic events with high reversibility rates after drug withdrawal. Close monitoring of AKI is crucial during polymyxin therapy, particularly, for elderly patients, patients who have high baseline creatinine, and using other nephrotoxic drugs.
Keyphrases
- gram negative
- end stage renal disease
- multidrug resistant
- newly diagnosed
- chronic kidney disease
- escherichia coli
- ejection fraction
- drug induced
- acute kidney injury
- pseudomonas aeruginosa
- drug resistant
- adverse drug
- prognostic factors
- acinetobacter baumannii
- emergency department
- uric acid
- mesenchymal stem cells
- metabolic syndrome
- bone marrow
- clinical evaluation