Ageing-related tau astrogliopathy severely affecting the substantia nigra.

Hidetomo TanakaSeojin LeeIvan Martinez-ValbuenaBlas CoutoMaria Carmela TartagliaJavier Sanchez-Ruiz de GordoaM Elena ErroAnthony E LangShelley L ForrestGabor G Kovacs

Published in: Neuropathology and applied neurobiology (2024)

We propose NITAG is a rare neuropathological feature, and not a distinct disease entity, in the frame of multiple system ARTAG, represented by abundant tau-positive astrocytes in various brain regions but having the highest density in the SN. The concept of NITAG allows the stratification of cases with various background pathologies to understand its relevance and contribution to neuronal dysfunction.

Keyphrases

cerebrospinal fluid
cerebral ischemia
machine learning
white matter
oxidative stress
deep learning
drug induced