Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma.
Nicholas H ChakiryanYoungchul KimAnders E BerglundAndrew ChangGregory J KimmelAli HajiranJonathan NguyenCarlos Moran SeguraDaryoush Saeed-VafaEsther N KatendeNeale Lopez-BlancoJad ChahoudPhillip M RappoldPhilippe E SpiessMichelle FournierDaniel JeongLiang WangJamie K TeerJasreman DhillonFengshen KuoAbraham Ari HakimiPhilipp M AltrockJames J MuleBrandon J ManleyPublished in: Journal for immunotherapy of cancer (2023)
Geospatial clustering of CD163+M2 like TAMs into the stromal compartment at the tumor-stromal interface was associated with poor clinical outcomes and CD8+T cell terminal exhaustion.
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