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Synthesis of Cerium Oxide Nanoparticles in a Bacterial Nanocellulose Matrix and the Study of Their Oxidizing and Reducing Properties.

Nina B MelnikovaDarina MalyginaVitaly KorokinHayder Al-AzzawiDaria ZdorovaEvgeniy MokshinElena V LiyaskinaIrina KurgaevaViсtor V Revin
Published in: Molecules (Basel, Switzerland) (2023)
A soft synthesis of nanoceria with non-stoichiometric composition (33% Ce 3+ /67% Ce 4+ ) named CeO 2 NPs in bacterial cellulose (BC) matrix in the form of aerogel and hydrogel with controlled CeO 2 NPs content was proposed. The advantage of CeO 2 NPs synthesis in BC is the use of systemic antacid API-trisamine as a precursor, which did not destruct cellulose at room temperature and enabled a reduction in the duration of synthesis and the number of washes. Moreover, this method resulted in the subsequent uniform distribution of CeO 2 NPs in the BC matrix due to cerium (III) nitrate sorption in the BC matrix. CeO 2 NPs (0.1-50.0%) in the BC matrix had a fluorite structure with a size of 3-5 nm; the specific surface area of the composites was 233.728 m 2 /g. CeO 2 NPs in the BC-CeO 2 NPs composite demonstrated SOD-like activity in the processes of oxidation and reduction of cytochrome c (cyt c 3+ /cyt c 2+ ), as well as epinephrine to inhibit its auto-oxidation in aqueous solutions by 33-63% relative to the control. In vitro experiments on rat blood showed a decrease in the MDA level and an increase in the activity of antioxidant defense enzymes-SOD by 24% and G6PDH by 2.0-2.5 times. Therefore, BC-CeO 2 NPs can be proposed for wound healing as antioxidant material.
Keyphrases
  • oxide nanoparticles
  • room temperature
  • oxidative stress
  • ionic liquid
  • nitric oxide
  • anti inflammatory
  • drinking water
  • hydrogen peroxide
  • amyotrophic lateral sclerosis
  • energy transfer
  • hyaluronic acid
  • quantum dots