Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance.

Dai-Min XiangWen SunTengfei ZhouCheng ZhangZhuo ChengShi-Chao LiWeiqi JiangRuoyu WangGongbo FuXiuliang CuiGuojun HouGuang-Zhi JinHengyu LiCaiying HouHui LiuHong-Yang WangJin Ding

Published in: Gut (2019)

Our findings uncovered HLF as a novel oncofetal protein and revealed the crucial role of the HLF/c-Jun axis in HCC development and sorafenib response, rendering HLF as an optimal target for the prevention and intervention of HCC.

Keyphrases

amino acid
protein protein
binding protein