Unconventional T Cells in the Pancreatic Tumor Microenvironment: Thinking Outside the Box.

Unlike conventional MHC-reactive T cells, unconventional T cells have emerged as an abundant component of the human immune system because of their role in tumor immunology. In this issue of Cancer Discovery, Hundeyin and colleagues have identified a population of unconventional T cells in pancreatic tumors that can reprogram the immune evasive components of the tumor to promote immunogenicity and thus are critical for the development of novel cell-based therapy in pancreatic cancer.See related article by Hundeyin et al., p. 1288.