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Abnormal functional connectivity profiles predict drug responsiveness in patients with temporal lobe epilepsy.

Kangrun WangFangfang XieChaorong LiuLangzi TanJialinzi HePing HuMin ZhangGe WangFenghua ChenBo XiaoWei-Hua LiaoLili Long
Published in: Epilepsia (2021)
In patients with TLE who would not achieve seizure freedom with current antiseizure medications, the functional connectivity between the hippocampus and central nodes of the DMN, CCN, and language network was disrupted, leading to language decline. Independent of hippocampal sclerosis, abnormalities, especially the effective connectivity from the hippocampus to the DMN, were predictive biomarkers of drug responsiveness in patients with TLE.
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