Studying ferroptosis and iron metabolism pre- and post-radiotherapy treatment in breast cancer patients.

Sanaa A El-BenhawyIbrahim G AbdelrhmanNadia A SadekEnayat I FahmyAhmed A AboGabalHossam ElmasrySally A M SalehOla A SakrMona Nagy ElwanyMaha Abubakr Feissal Rabie

Published in: Journal of the Egyptian National Cancer Institute (2023)

Radiotherapy induced ferroptosis in breast cancer patients as a new cell death mechanism and PTGS2 is a biomarker of ferroptosis. Iron modulation is a useful approach for the treatment of BC especially if combined with targeted therapy and immune-based therapy. Further studies are warranted to be translated into clinical compounds.

Keyphrases

cell death
early stage
radiation therapy
radiation induced
squamous cell carcinoma
combination therapy
high glucose
stress induced
case control