Identification of differentially expressed genes in mouse embryonic stem cell under hypoxia.

Published in: Genes & genomics (2020)

We discovered that H2afz could be a new target gene that functions in hypoxia-induced differentiation in mESCs and have revealed that it is involved in maintaining the pluripotency of mESCs in the early stages of differentiation. These findings will provide insights into mechanisms of hypoxia-mediated differentiation of mESCs during early development.

Keyphrases

stem cells
genome wide
endothelial cells
bioinformatics analysis
copy number
gene expression
genome wide analysis
transcription factor