Wolbachia introduction into Lutzomyia longipalpis (Diptera: Psychodidae) cell lines and its effects on immune-related gene expression and interaction with Leishmania infantum.

Daniela da Silva GonçalvesIñaki Iturbe-OrmaetxeAndrea Martins-da-SilvaErich Loza TelleriaMarcele Neves RochaYara M Traub-CseköScott L O'NeillMaurício Roberto Viana Sant'AnnaLuciano Andrade Moreira

Published in: Parasites & vectors (2019)

Initial strong immune responses of LL5 cells might explain the inefficiency of stable infections in these cells while we found that Lulo cells are more permissive to infection with Wolbachia causing an effect on the cell immune system, but not against in vitro L. infantum interaction. This establishes Lulo cells as a good system for the adaptation of Wolbachia in L. longipalpis.

Keyphrases

induced apoptosis
cell cycle arrest
gene expression
immune response
endoplasmic reticulum stress
dna methylation
oxidative stress
pi k akt