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Innate Lymphoid Cells and T Cells Contribute to the Interleukin-17A Signature Detected in the Synovial Fluid of Patients With Juvenile Idiopathic Arthritis.

Elizabeth C RosserHannah LomDavid BendingChantal L DuurlandMona Bajaj-ElliottLucy R Wedderburn
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
We demonstrate that the strength of the IL-17A signature in JIA SFMCs is determined by multiple lymphoid cell types, including NCR- ILC3s and IL-17A+CD4+, IL-17A+CD8+, and IL-17A+ γδ T cells. These observations may have important implications for the development of stratified therapeutics.
Keyphrases
  • juvenile idiopathic arthritis
  • induced apoptosis
  • cell therapy
  • disease activity
  • cell proliferation