Innate Lymphoid Cells and T Cells Contribute to the Interleukin-17A Signature Detected in the Synovial Fluid of Patients With Juvenile Idiopathic Arthritis.
Elizabeth C RosserHannah LomDavid BendingChantal L DuurlandMona Bajaj-ElliottLucy R WedderburnPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
We demonstrate that the strength of the IL-17A signature in JIA SFMCs is determined by multiple lymphoid cell types, including NCR- ILC3s and IL-17A+CD4+, IL-17A+CD8+, and IL-17A+ γδ T cells. These observations may have important implications for the development of stratified therapeutics.