Safety and Efficacy of Coma Induction Following First-Line Treatment in Status Epilepticus: A 2-Center Study.
Pia De StefanoSira Maria BaumannSaskia SemmlackStephan RüeggStephan MarschMargitta SeeckRaoul SutterPublished in: Neurology (2021)
This study provides Class III evidence that early induction of artificial coma after unsuccessful first-line treatment for SE is associated with shorter duration of SE and ICU and hospital stays compared to the use of a second-line nonanesthetic antiseizure drug instead of or before anesthetics, without an associated increase in complications.