Chimeric antigen receptor T cells in the fast lane among autoimmune disease therapies.
Zhoujie DingDavid Mathew TarlintonPublished in: Clinical & translational immunology (2024)
In this commentary, we highlight recent studies demonstrating the feasibility and promise of chimeric antigen receptor (CAR) T-cell therapy in treating a number of autoimmune disorders including systemic lupus erythematosus and compare CAR T cells to other therapies aimed at depleting B-lineage cells in treating such diseases.
Keyphrases
- cell therapy
- systemic lupus erythematosus
- induced apoptosis
- multiple sclerosis
- stem cells
- mesenchymal stem cells
- cell cycle arrest
- disease activity
- drug induced
- single cell
- signaling pathway
- endoplasmic reticulum stress
- big data
- oxidative stress
- case control
- cell death
- rheumatoid arthritis
- machine learning
- deep learning
- cell fate