Accuracy of Xpert Ultra for the diagnosis of paediatric tuberculosis in a low TB burden country: a prospective multicentre study.
David Aguilera-AlonsoGonzalo Solís-GarcíaAntoni Noguera-JulianJulián González-MartínAngely Román CobeñaFernando Baquero-ArtigaoCarlos Toro RuedaPaula Rodríguez-MolinoIván Bloise SánchezTeresa VallmanyaAlbert Bernet-SánchezLaura Minguell DomingoAdriana RubioJesús Saavedra-LozanoMaría Jesús Ruiz-SerranoDaniel Blázquez-GameroPaula Lopez-RoaDavid Gómez-PastranaMaría Dolores López PrietoEva María López MedinaAna Gil-BrusolaAndrea Martín NaldaAntonio Soriano-ArandesMaría Teresa Tórtola FernándezLola Falcón-NeyraVerónica González GalánMarc TebrueggeBegoña SantiagoPublished in: Thorax (2022)
In children with pulmonary TB in a low burden setting, Xpert Ultra has significantly higher sensitivity than the previous generation of Xpert assay and only marginally lower specificity. Therefore, in children undergoing evaluation for suspected pulmonary TB, Xpert Ultra should be used in preference to Xpert MTB/RIF whenever possible.