Soluble levels of 4-1BB (CD137) and OX40 (CD134) are associated with cancer progression in gastric adenocarcinoma.
Cecilia Araújo Carneiro LimaMário Rino MartinsRogerio Luiz Dos SantosLuciana Mata da SilvaJeronimo Paulo Assis Da SilvaNora Manoukian ForonesLeuridan Cavalcante TorresPublished in: Journal of surgical oncology (2024)
The sOX40 and s4-1BB-mediated T cell interactions may be involved in antitumor immune responses in GC, possibly favoring tumor escape and progression. Serum levels of sOX40 and s4-1BB are associated with staging in GC and may constitute biomarkers for prognosis, as well as potential targets for immunotherapy.