Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis.

Wenjie ZhengMin YaoMengna WuJunling YangDengfu YaoLi Wang

Published in: Journal of translational medicine (2020)

Taken together, the oncogenic sCLU might promote CSC phenotype via activating AKT/GSK3β/β-catenin axis, suggesting that sCLU was a potential molecular-target for HCC therapy.

Keyphrases

signaling pathway
epithelial mesenchymal transition
cancer stem cells
cell proliferation
pi k akt
transcription factor
human health
single molecule
risk assessment