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Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells.

Zhi ChenDi WenFen WangChunbo WangYang Lei
Published in: Reproductive biology and endocrinology : RB&E (2019)
The present study suggests that PA induces apoptosis via ER stress and curcumin ameliorates PA-induced apoptosis by inhibiting ER stress in MLTC-1 cells. This study suggests the application of curcumin as a potential therapeutic agent for the treatment of obesity-related male infertility.
Keyphrases
  • induced apoptosis
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • metabolic syndrome
  • weight loss
  • physical activity
  • weight gain
  • replacement therapy