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A self-assembled DNA nanostructure as a FRET nanoflare for intracellular ATP imaging.

Shijun CaiJiaoli WangJing LiBing ZhouChunmei HeXiangxian MengJin HuangKemin Wang
Published in: Chemical communications (Cambridge, England) (2021)
Due to the incorporation of gold nanoparticles (AuNPs), previously reported AuNP-based FRET nanoflares still have some problems, such as non-negligible cytotoxicity and a time-consuming preparation procedure. In this communication, a novel AuNP-free FRET nanoflare for intracellular ATP imaging is developed based on a DNA nanostructure, which is self-assembled through cyclic U-type hybridization only involving a certain number of DNA strands.
Keyphrases
  • single molecule
  • gold nanoparticles
  • living cells
  • high resolution
  • fluorescent probe
  • circulating tumor
  • energy transfer
  • mental health
  • reactive oxygen species