Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.

Kyoko NakamuraAnkur KarmokarPaul M FarringtonNeil H JamesAntonio Ramos-MontoyaSusan J BickertonGareth D HughesTimothy M IllidgeElaine B CadoganBarry R DaviesSimon J DovediViia Valge-Archer

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Blocking the NHEJ DNA repair pathway with AZD7648 in combination with RT leads to durable immune-mediated tumor control.

Keyphrases

dna repair
dna damage
early stage
dna damage response
circulating tumor
single molecule
squamous cell carcinoma
locally advanced
radiation induced
oxidative stress
signaling pathway