Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia.

Muluwork GetahunHenry M BlumbergGobena AmeniDereje BeyeneRussell R Kempker

Published in: PloS one (2022)

Our findings suggest a role for rifabutin treatment in a subset of RR TB patients, thus potentially preserving an important drug class. The high proportion of moderate level INH resistant among MDR Mtb isolates indicates the potential benefit of high dose isoniazid treatment in a high proportion of katG gene harboring MDR Mtb isolates.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
high dose
end stage renal disease
chronic kidney disease
low dose
ejection fraction
newly diagnosed
emergency department
genome wide
transcription factor
patient reported
drug induced