Rethinking the definition of 'less intensive' for venetoclax-combining regimens in acute myeloid leukaemia patients.
Erika BorlenghiA M RoccaroChiara CattaneoPublished in: British journal of haematology (2023)
Invasive fungal infections (IFIs), mainly due to pulmonary aspergillosis, are considered a serious complication in acute leukaemia, with an unfavourable impact on patient. In this well-conducted retrospective study, Reynolds et al. suggest that the use of posaconazole prophylaxis in association with venetoclax plus hypomethylating agents or chemotherapy leads to a reduction of IFI incidence. Therapeutic drug monitoring of posaconazole levels is suggested, even if no correlation with IFI risk has been demonstrated.
Keyphrases
- liver failure
- respiratory failure
- end stage renal disease
- newly diagnosed
- ejection fraction
- drug induced
- aortic dissection
- pulmonary hypertension
- acute myeloid leukemia
- case report
- dendritic cells
- bone marrow
- chronic lymphocytic leukemia
- risk factors
- locally advanced
- intensive care unit
- immune response
- patient reported
- mechanical ventilation