The spread of bacterial resistance is a rising serious threat to global public health, and has created an urgent need for the development of a new generation of antibacterial nano-agents to take the place of antibiotics. In this work, a multifunctional nanoplatform based on boron nanosheet (B NS)-coated quaternized chitosan (QCS) and the nitric oxide (NO) donor N , N '-di- sec -butyl- N , N '-dinitroso-1,4-phenylenediamine (BNN6) (B-QCS-BNN6) was prepared via a liquid-phase exfoliation and electrostatic adsorption method. The 2D B NSs could convert near-infrared (NIR) light into heat energy as well as assemble positively charged QCS and BNN6 to trap negatively charged bacteria, and the positive charge made it easily captured by bacteria, increasing the opportunities for NO diffusion to the bacterial surface. The B-QCS-BNN6 nanoplatform not only exhibited photothermal therapy (PTT) efficacy but could also control NO release precisely after stimulation with an 808 nm laser for the rapid and effective treatment of typical Gram-negative and Gram-positive bacteria. The enhanced PTT/NO antibacterial function achieved >99.9% inactivation of bacteria within 5 min. Furthermore, this synergetic antibacterial strategy could also be conveniently employed for highly efficient disinfection of a methicillin-resistant Staphylococcus aureus (MRSA) infected wound and promotion of the reconstruction of damaged tissues for in vivo MRSA-infected wound therapy.
Keyphrases
- methicillin resistant staphylococcus aureus
- wound healing
- gram negative
- nitric oxide
- photodynamic therapy
- highly efficient
- cancer therapy
- public health
- staphylococcus aureus
- drug delivery
- multidrug resistant
- silver nanoparticles
- drug release
- hydrogen peroxide
- anti inflammatory
- quantum dots
- drinking water
- fluorescence imaging
- ionic liquid
- essential oil
- stem cells
- replacement therapy
- gold nanoparticles
- high speed
- surgical site infection
- tandem mass spectrometry
- solid phase extraction