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POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy.

Rita B RestaniRita F PiresAnna TolmatchevaRita CabralPedro Viana BaptistaAlexandra Ramos FernandesTeresa CasimiroVasco D B BonifácioAna Aguiar-Ricardo
Published in: ChemistryOpen (2018)
POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
Keyphrases
  • drug delivery
  • cancer therapy
  • induced apoptosis
  • locally advanced
  • drug release
  • squamous cell carcinoma
  • cell cycle arrest
  • wound healing
  • oxidative stress
  • radiation therapy
  • chemotherapy induced
  • case control