L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift.
Helene QuelquejayRida Al-RifaiMichele SilvestroMarie VandestienneIrmine Loisel-FerreiraTristan MiraultHenrion DanielXiaodan ZhongIcia Santos-ZasGuillaume GoudotPaul AlayracEstelle RobidelGwennhael AutretDaniel BalvaySoraya TalebAlain TedguiChantal M BoulangerAlma ZerneckeAntoine-Emmanuel SalibaJuliette HadchouelBhama RamkhelawonClément CochainSonia BergayaXavier JeunemaitreHafid Ait OufellaPublished in: Circulation research (2024)
deletion promotes VSMC phenotype switch toward a pathogenic proinflammatory phenotype, orchestrating deleterious vascular remodeling and spontaneous severe aortitis in mice.