Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells.

Behnoosh TayebiMahnaz BabaahmadiMohammad PakzadMostafa HajinasrollahFarhad MostafaeiShahrbanoo JahangiriAmir KamaliHossein BaharvandMohamadreza Baghaban EslaminejadSeyedeh-Nafiseh HassaniEnsiyeh Hajizadeh-Saffar

Published in: Stem cell research & therapy (2022)

The results suggest that local and systemic administrations of xenogeneic BM-cMSCs in both sexes of SD rats do not cause toxicity during the subacute and subchronic periods of time. Also, BM-cMSCs were non-tumorigenic in nude mice.

Keyphrases

bone marrow
endothelial cells
oxidative stress
stem cell transplantation
mesenchymal stem cells
induced pluripotent stem cells
adipose tissue
oxide nanoparticles
high dose
insulin resistance
drug induced