The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway.

Xiaohui WangChao JiangYongyuan ZhangZhe ChenHong FanYuyang ZhangZhiyuan WangFang TianJing LiHao YangDing-Jun Hao

Published in: Cell & bioscience (2022)

OECs activated by LPS and CCM have a pro-angiogenic effect and can effectively promote angiogenesis and improve the microenvironment at the injury site when transplanted in the injured spinal cord. This potentiated ability of OECs to provide pro-angiogenic effects is likely mediated through the PI3K/Akt pathway.

Keyphrases

anti inflammatory
spinal cord
endothelial cells
induced apoptosis
vascular endothelial growth factor
cell cycle arrest
stem cells
wound healing
inflammatory response
spinal cord injury
endoplasmic reticulum stress
oxidative stress