Facile synthesis and antiproliferative activity of new 3-cyanopyridines.

Hassan M Abdel-AzizSobhi Mohamed GomhaAbdelaziz A El-SayedYahia Nasser MabkhotAbdulrhman AlsayariAbdullatif Bin Muhsinah

Published in: BMC chemistry (2019)

The results revealed that the pyridine derivatives 5c and 5d (IC50 = 1.46, 7.08 µM, respectively) have promising antitumor activity against liver carcinoma cell line (HEPG2), compared to the reference drug, doxorubicin.

Keyphrases

drug delivery
single cell
cancer therapy
adverse drug
drug induced
structure activity relationship