NRF2 Activation Reprogrammes Defects in Oxidative Metabolism to Restore Macrophage Function in COPD.
Eilise M RyanPranvera SadikuPatricia CoelhoEmily R WattsAiliang ZhangAndrew J M HowdenManuel A Sanchez-GarciaMartin BewleyJoby ColeBrian J McHughWesley VermaelenBart GhesquierePeter CarmelietGiovanny Rodriguez BlancoAlex Von KriegsheimYolanda SanchezWilliam RumseyJames F CallahanGeorge CooperNicholas ParkinsonJohn Kenneth BaillieDoreen A CantrellJohn McCaffertyGourab ChoudhuryDave SinghDavid H DockrellMoira K B WhyteSarah R WalmsleyPublished in: American journal of respiratory and critical care medicine (2023)
In COPD an inherent loss of metabolic plasticity leads to metabolic exhaustion and reduced redox capacity which can be rescued by activation of the NRF2 pathway. Targeting these defects, via NRF2 augmentation, may therefore present an attractive therapeutic strategy for the treatment of the aberrant airway inflammation described in COPD.