Chronic hepatitis B baseline viral load and on-treatment liver cancer risk: A multinational cohort study of HBeAg-positive patients.
Won-Mook ChoiTerry Cheuk-Fung YipW Ray KimLeland J YeeCraig Brooks-RooneyTristan CurteisLaura J ClarkZarena JafryChien-Hung ChenChi-Yi ChenYi-Hsiang HuangYoung-Joo JinDae Won JunJin-Wook KimNeung Hwa ParkCheng-Yuan PengHyun Phil ShinJung Woo ShinYao-Hsu YangGrace Lai-Hung WongYoung-Suk LimPublished in: Hepatology (Baltimore, Md.) (2024)
In a multinational cohort of adult patients with HBeAg-positive without cirrhosis and with chronic hepatitis B, baseline HBV viral load was significantly associated with HCC risk despite antiviral treatment. Patients with the highest viral load who initiated treatment had the lowest long-term risk of HCC development.