Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer.
Ying JinYamei ChenHuarong TangXiao HuShawna Marie HubertQian LiDan SuHaimiao XuYun FanXinmin YuQixun ChenJinshi LiuWei HongYujin XuHuan DengDapeng ZhuPansong LiYuhua GongXuefeng XiaCarl M GayJianjun ZhangMing ChenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
PI3K/AKT pathway activation may be one potential mechanism underlying therapeutic resistance of SCLC. This finding warrants further investigation and provides a possible approach to reverse resistance to chemo/radiotherapy.