GBP5 exacerbates rosacea-like skin inflammation by skewing macrophage polarization towards M1 phenotype through the NF-KB signalling pathway.

Lei ZhouHan ZhaoHe ZhaoXin MengZhixiang ZhaoHongfu XieJi LiYan TangYiya Zhang

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

Together, our study revealed the important role of macrophages in rosacea and identified GBP5 as a key regulator of rosacea by inducing M1 macrophage polarization via NF-κB signalling pathways.

Keyphrases

oxidative stress
signaling pathway
lps induced
pi k akt
nuclear factor
transcription factor
inflammatory response
single cell
immune response
cell proliferation
toll like receptor