Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode.

Shaohui LeiZhuo ZouKangling TianYan ZhengMei DingGuangxuan HuHong Bin YangChun Xian GuoChangming LiFang Xin Hu

Published in: Chemical communications (Cambridge, England) (2024)

A W-doped Pt modified graphene oxide (Pt-W-GO) electrochemical microelectrode was developed to detect hydrogen peroxide (H 2 O 2 ) in real time at a subcellular scale. Interestingly, results showed that the concentration of H 2 O 2 in the nucleus of HeLa cells was 2.68 times and 0.51 times that in the extracellular membrane and cytoplasm, respectively.

Keyphrases

hydrogen peroxide
quantum dots
cell cycle arrest
nitric oxide
deep brain stimulation
induced apoptosis
label free
highly efficient
gold nanoparticles
metal organic framework
cell death
visible light
endoplasmic reticulum stress
signaling pathway
molecularly imprinted
high resolution