A Personalized Neoantigen Vaccine in Combination with Platinum-Based Chemotherapy Induces a T-Cell Response Coinciding with a Complete Response in Endometrial Carcinoma.
Alexandre HarariApostolos SarivalasisKaat de JongeAnne-Christine ThierryFlorian HuberCaroline BoudousquieLaetitia RossierAngela OrcurtoMartina ImbimboPetra BaumgaertnerMichal Bassani-SternbergLana Elias KandalaftPublished in: Cancers (2021)
Endometrial cancer (EC) is a common gynecological malignancy and the fourth most common malignancy in European and North American women. Amongst EC, the advanced serous, p53-mutated, and pMMR subtypes have the highest risk of relapse despite optimal standard of care therapy. At present, there is no standard of care maintenance treatment to prevent relapse among these high-risk patients. Vaccines are a form of immunotherapy that can potentially increase the immunogenicity of pMMR, serous, and p53-mutated tumors to render them responsive to check point inhibitor-based immunotherapy. We demonstrate, for the first time, the feasibility of generating a personalized dendritic cell vaccine pulsed with peptide neoantigens in a patient with pMMR, p53-mutated, and serous endometrial adenocarcinoma (SEC). The personalized vaccine was administered in combination with systemic chemotherapy to treat an inoperable metastatic recurrence. This treatment association demonstrated the safety and immunogenicity of the personalized dendritic cell vaccine. Interestingly, a complete oncological response was obtained with respect to both radiological assessment and the tumor marker CA-125.
Keyphrases
- endometrial cancer
- dendritic cells
- high grade
- locally advanced
- healthcare
- squamous cell carcinoma
- end stage renal disease
- palliative care
- small cell lung cancer
- regulatory t cells
- free survival
- newly diagnosed
- ejection fraction
- prostate cancer
- stem cells
- case report
- peritoneal dialysis
- prognostic factors
- adipose tissue
- radical prostatectomy
- type diabetes
- radiation therapy
- wild type
- minimally invasive
- robot assisted
- patient reported outcomes
- patient reported
- health insurance
- breast cancer risk