Microvascular Dysfunction in Blood-Brain Barrier Disruption and Hypoperfusion Within the Infarct Posttreatment Are Associated With Cerebral Edema.
Felix Chun Fai NgLeonid ChurilovNawaf YassiTimothy John KleinigVincent N ThijsTeddy Y WuDarshan G ShahHelen M DeweyGargan SharmaPatricia M DesmondBernard YanMark W ParsonsGeoffrey Alan DonnanStephen M DavisPeter J MitchellRichard LeighBruce C V Campbellnull nullPublished in: Stroke (2021)
BBB disruption and persistent hypoperfusion in the infarct after reperfusion treatment is associated with space-occupying cerebral edema. Further studies evaluating microvascular dysfunction during the post-hyperacute period as biomarkers of poststroke edema and potential therapeutic targets are warranted.