Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening: a multicountry patient-level meta-analysis of 141,220 screened individuals.
Nicole LowresJake OlivierTze-Fan ChaoShih-Ann ChenYi ChenAxel Cosmus Pyndt DiederichsenDavid A FitzmauriceJuan José Gómez DoblasJoseph A HarbisonJeff S HealeyFrederick David Richard HobbsFemke KaasenbroodWilliam KeenVivian W LeeJes Sanddal LindholtGregory Yoke Hong LipGeorges H MairesseJonathan MantJulie W MartinEnrique Martín-RioboóDavid D McManusJavier Muñiz GarcíaThomas MunzelJuliet NakamyaLis NeubeckJessica J OrchardLuis Ángel Pérula-de TorresMarco ProiettiF Russell QuinnAndrea K RoalfeRoopinder K SandhuRenate B SchnabelBreda SmythApurv SoniRobert TielemanJiguang WangPhilipp S WildBryan P YanBen FreedmanPublished in: PLoS medicine (2019)
People with screen-detected AF are at elevated calculated stroke risk: above age 65, the majority have a Class-1 OAC recommendation for stroke prevention, and >70% have ≥1 additional stroke risk factor other than age/sex. Our data, based on the largest number of screen-detected AF collected to date, show the precise relationship between yield and estimated stroke risk profile with age, and strong dependence for NNS-RX on the age distribution of the population to be screened: essential information for precise cost-effectiveness calculations.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- left atrial
- catheter ablation
- left atrial appendage
- direct oral anticoagulants
- heart failure
- high throughput
- risk factors
- healthcare
- electronic health record
- cerebral ischemia
- molecular dynamics
- molecular dynamics simulations
- case report
- venous thromboembolism
- acute coronary syndrome
- deep learning
- breast cancer risk