Proteomic changes of botulinum neurotoxin injection on muscle growth in children with spastic cerebral palsy.

Xubo YangHongmei TangLu HeTingting PengJinling LiJingbo ZhangLiru LiuHongyu ZhouZhaofang ChenJingyi ZhaoYage ZhangMengru ZhongMingshan HanMengqing ZhangHuiran NiuKai-Shou Xu

Published in: Proteomics. Clinical applications (2024)

BoNT-A injection could lead to a disruption of protein levels and signaling pathways, a condition subsequently associated with muscle growth. This finding might aid clinicians in optimizing the management of spasticity in children with CP.

Keyphrases

cerebral palsy
young adults
skeletal muscle
signaling pathway
botulinum toxin
ultrasound guided
spinal cord injury
palliative care
binding protein
small molecule
cell proliferation
epithelial mesenchymal transition
endoplasmic reticulum stress