Novel epigenetic network biomarkers for early detection of esophageal cancer.

Alok K MaityTimothy C StoneVanessa WardAmy P WebsterZhen YangAine HoganHazel McBainMargaraet DukuKai Man Alexander HoPaul WolfsonDavid G Grahamnull nullStephan BeckAndrew E TeschendorffLaurence B Lovat

Published in: Clinical epigenetics (2022)

Given our observations that a CCL20 chemokine network is overactivated in EAC tissue and saliva from EAC patients, and that in independent studies CCL20 has been found to be overactivated in EAC tissue infected with the bacterium F. nucleatum, a bacterium that normally inhabits the oral cavity, our results highlight the possibility of using DNAm measurements in saliva as a proxy for changes occurring in the esophageal epithelium. Both the CTNND2/CCL20 modules represent novel promising network biomarkers for EAC that merit further investigation.

Keyphrases

liver fibrosis
end stage renal disease
liver injury
ejection fraction
newly diagnosed
gene expression
network analysis
peritoneal dialysis
patient reported outcomes