Login / Signup

Individualised dosing algorithm and personalised treatment of high-dose rifampicin for tuberculosis.

Robin J SvenssonKatarina NiwardLina Davies ForsmanJudith BruchfeldJakob PauesErik EliassonThomas SchönUlrika S H Simonsson
Published in: British journal of clinical pharmacology (2019)
A new up-to-date exposure target for Bayesian dose optimisation suited for high-dose rifampicin was derived. Using measured plasma concentrations coupled with Bayesian forecasting allowed prediction of the future dose whilst accounting for the auto-induction, saturable pharmacokinetics and high between-occasion variability of rifampicin.
Keyphrases