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Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets.

Momoko Tajiri
Published in: Acta parasitologica (2021)
This study found 18 peptide motifs which potentially have strong interactions with one or more of the Alba superfamily proteins from P. falciparum. Considering the large fraction of post-translational modification-related peptide motifs identified from this work, one or more of the protein modification pathways could serve as a good target for malaria treatment.
Keyphrases
  • plasmodium falciparum
  • endothelial cells
  • protein protein
  • amino acid
  • pseudomonas aeruginosa
  • small molecule
  • transcription factor
  • cystic fibrosis
  • smoking cessation
  • replacement therapy