Can data from paediatric cohorts solve the COVID-19 puzzle?
Lien Anh Ha DoJeremy AndersonEdward Kim MulhollandPaul Vincent LicciardiPublished in: PLoS pathogens (2020)
COVID-19, caused by SARS-CoV-2, is significantly more severe in adults than in children. The biological reasons for this difference remain to be elucidated. We have compared the most recent virological and immunological data related to COVID-19 between adults and children and contrasted this with earlier data from severe acute respiratory syndrome (SARS) caused by the related SARS-CoV-1 in 2003. Based on these available data, a number of hypotheses are proposed to explain the difference in COVID-19 clinical outcomes between adults and children. NF-kB may be a key factor that could explain the severe clinical manifestations of COVID-19 in adults as well as rare complications associated with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in paediatric COVID-19 patients.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- electronic health record
- young adults
- intensive care unit
- emergency department
- big data
- oxidative stress
- signaling pathway
- early onset
- case report
- immune response
- risk factors
- lps induced
- hiv infected
- deep learning
- pi k akt
- cell proliferation
- toll like receptor
- inflammatory response
- nuclear factor