Database-aided ultrahigh-performance liquid chromatography Q-Exactive-Orbitrap tandem mass spectrometry putatively identifies 16 unexpected compounds and three anticounterfeiting pharmacopoeia quality markers for Perillae Fructus.
Ban ChenShuangshuang LiuXican LiRongxin CaiChunhou LiYuchen HuJiangtao SuTongxun LeiPublished in: Rapid communications in mass spectrometry : RCM (2024)
The database-aided UHPLC/Q-Exactive-Orbitrap MS/MS can identify at least 27 compounds in PF. Of these, 16 compounds are unexpected, and three compounds (matrine, scopolamine, and RosA) should be considered anticounterfeiting pharmacopoeia Q-markers of PF.
Keyphrases
- ultra high performance liquid chromatography
- tandem mass spectrometry
- liquid chromatography
- high resolution mass spectrometry
- high performance liquid chromatography
- simultaneous determination
- gas chromatography
- ms ms
- mass spectrometry
- solid phase extraction
- high resolution
- liquid chromatography tandem mass spectrometry
- adverse drug
- genome wide
- drug induced