Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex.
Chen XuGe ZhangXinjian WangXiaozhi HuangJiayin ZhangShuxian HanJinxi WangDuane D HallRuoqing XuFeng HeXing ChangFudi WangWenjun XieZhichao WuLong-Sheng SongPeidong HanPublished in: Circulation (2024)
Ptpn23 is essential for cardiac T-tubule formation and maintenance along Z-discs. During postnatal heart development, Ptpn23 interacts with sarcomeric α-actinin and coordinates the assembly of the DGC at costameres to sculpt T-tubule spatial patterning and morphology.