Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.
Cecilia MariniVanessa CossuTiziana BonifacinoMatteo BaucknehtCarola TorazzaSilvia BrunoPatrizia CastellaniSilvia RaveraMarco MilaneseConsuelo VenturiSebastiano CarlonePatrizia PiccioliLaura EmioniteSilvia MorbelliAnna Maria OrengoMaria Isabella DoneganiAlberto MiceliStefano RaffaStefano MarraAlessio SignoriKatia CorteseFederica GrilloRoberto FioccaGiambattista BonannoGianmario SambucetiPublished in: EJNMMI research (2020)
Skeletal muscle of SOD1G93A mice reproduces the increased FDG uptake observed in ALS patients. This finding reflects the selective activation of the ER-PPP in response to significant redox stress associated with alterations of mitochondrial ultrastructure, networking, and connection with the ER itself. This scenario is less severe in cardiomyocytes suggesting a relevant role for either communication with synaptic plaque or contraction dynamics.
Keyphrases
- skeletal muscle
- end stage renal disease
- insulin resistance
- pet ct
- newly diagnosed
- chronic kidney disease
- pet imaging
- ejection fraction
- positron emission tomography
- prognostic factors
- amyotrophic lateral sclerosis
- coronary artery disease
- peritoneal dialysis
- endoplasmic reticulum
- oxidative stress
- computed tomography
- type diabetes
- high fat diet induced
- patient reported outcomes
- endothelial cells
- adipose tissue
- prefrontal cortex
- wild type