Hetero-Diels-Alder click reaction of dithioesters for a catalyst-free indirect 18 F-radiolabelling of peptides.
Timothé MaujeanPatrice MarchandPatrick WagnerStéphanie RichéFrédéric BoissonNicolas GirardDominique BonnetMihaela GuleaPublished in: Chemical communications (Cambridge, England) (2022)
The HDA reaction of dithioesters was developed as a new click-reaction compatible with the indirect 18 F-labelling of peptides. It involves dithioester-peptides and a radiofluorinated diene as a novel prosthetic group. The method was applied to a PSMA-ligand for the in vivo detection of LNCap tumors in xenografted mice.