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CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation.

Mushriq Al-JazraweSteven XuRaymond PoonQingxia WeiJoanna PrzybylSushama VarmaMatt van de RijnBenjamin A Alman
Published in: Cancer research communications (2023)
Distinguishing between neoplastic (tumor) and non-neoplastic (stromal) cells within mesenchymal tumors is particularly challenging, because lineage-specific cell surface markers typically used in other cancers do not differentiate between the different cell subpopulations. Here, we developed a strategy combining clonal expansion with surface proteome profiling to identify markers for quantifying and isolating mutant and nonmutant cell subpopulations in desmoid tumors, and to study their interactions via soluble factors.
Keyphrases
  • single cell
  • cell surface
  • cell therapy
  • bone marrow
  • signaling pathway
  • genome wide
  • dna methylation
  • mesenchymal stem cells
  • young adults
  • wild type